• Home

New approach to cancer research aims to accelerate studies and reduce cost

Posted: Updated:

Houston ? A new model for improving how clinical trials are developed and conducted by bringing together academic cancer experts and pharmaceutical companies is being tested by research experts at The University of Texas 
MD Anderson Cancer Center.

An assessment of the alternative research model was published in the May 14 online issue of Cancer. The model was piloted in a multi-study leukemia research program established between MD Anderson and Bristol-Myers Squibb (BMS) and revamped how studies were designed and carried out.

Current methodology often limits patient access to and eligibility for studies, slows down drug development and increases costs. Since the 1980s, drug companies have employed Contract Research Organizations (CROs) – outside groups that have limited input from academic cancer experts and that focus on the one-drug, one-cancer approach to designing clinical trials with restrictive guidelines for patient eligibility.

The model allows researchers to arrive at findings more quickly, to conduct multiple clinical trials of pharmaceutical company drugs across several cancer types, to lessen expenses and to increase the likelihood of finding medical solutions more quickly. 
MD Anderson has more than 50 research partnerships and alliances with pharmaceutical companies, managed through its Strategic Industry Ventures group. 

Hagop Kantarjian, M.D., chair of Leukemia and co-author, Ferran Prat, Ph.D., J.D., senior vice president for Research Administration and Industry Ventures, believe the new research model addresses these needs.


“This cancer research model is flexible and modifiable according to existing needs because it does not pretend to create a ‘one-size-fits-all’ approach,” said Kantarjian. “These types of alliances have significant variations that accommodate the partnering drug company – its drug pipeline, research needs, financial benefits and other considerations.”

MD Anderson’s collaboration with BMS led to simultaneous trials using combinations of immunotherapies and other treatments for several leukemia types including chronic lymphocytic leukemia, acute myeloid leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. The trials include the first “triplet” immunotherapy study for leukemia, with results for all trials being analyzed by MD Anderson’s top immunotherapy researchers.

The collaboration has already led to the establishment of a new standard of care for treatment of chronic myeloid leukemia with an altered dose of the chemotherapy dasatinib, which has proved more effective and less toxic.

The BMS collaboration has resulted in unique study approaches including:

Allowing MD Anderson leukemia researchers exploration of BMS’ immune-oncology pipeline across multiple blood malignancies.
Providing high-risk patients, typically excluded from BMS-sponsored studies due to CRO restrictions, access to trials at the discretion of leukemia experts.
Granting a set level of funding for all trials tied to MD Anderson research programs with 

“The success of this initiative has resulted in program expansion in a number of directions,” said Prat. “BMS extended the program to other clinical and research departments at MD Anderson, and is partnering with other academic cancer treatment institutions. Our Leukemia department and other MD Anderson programs have also established similar alliances with leading drug industry partners.”

Co-authors on the article included David Steensma, M.D., Dana-Farber Cancer Center, Boston; Razelle Kurzrock, M.D., the University of California, San Diego; David Stewart, M.D., the University of Ottawa; Mikkael Sekeres, M.D., Cleveland Clinic; and Joseph Leveque, M.D., Armo Biosciences, Redwood City, Calif. All co-authors contributed equally.

    • Victoria bus stop dancer finds future in figures

      "I guess just going to the beat of the music I just make up my own dance," Victoria woman, Tracy Lopez said. 

    • Birthday wishes

      Happy Birthday to Sandra, Mandy, and Theresa.  If today is your Birthday, you share it with Drew Carey and Joan Collins. Have a good one!
    • Primary Runoff Election Results

      It's election night, and we have some preliminary results to tell you about. The Republican Representative for District 27 race seeming to be blow out in favor of Michael Cloud. With 35 precincts reporting, Cloud has 84 percent of the votes.  The Democratic race a little more intense. With 35 precincts reporting, Eric Holguin and Raul (Roy) Barrera are neck and neck. But Holguin appears to have pulled ahead with 53 percent. For the Democratic Gubernatorial race between ...

    • Bootfest 2018 announces their main stage lineup

      VICTORIA, TEXAS—Bootfest, Victoria's largest free festival, announced their Main Stage entertainment lineup on Monday, May 21. 

    • Cuero Senior gets surprise of a lifetime

      Its graduation time and for one Cuero highschool student, the event is made more meaningful by some surprise guests. Newscenter 25's David Gibson tells more about this touching tale. 

    • Victoria County Jail Faces AC Issues

      Victoria County Jail has experienced issues with the AC in their facility.

    • TxDMV Warns Buyers to Beware of Flood-Damaged Vehicles

      AUSTIN – Giving someone a new or used car as a graduation gift may earn you an “A” for effort, but failing to do your homework before buying could be a dangerous and costly mistake. M

    • Calhoun County Sheriff's Office 2017 drug seizures report

      Calhoun County Sheriff's Office has released their 2017 Drug Seizures Report.  Below is a list of 2017 drug seizures by Calhoun County Sheriff's Office. 

    • Calhoun County SO, resident issue warning on mail diversion scam

      The Calhoun County Sheriff's Office is warning residents of a mail diversion scam. A Port Lavaca resident had their address changed through the United States Postal Service without his knowledge. The scammer was able to obtain personal mail, including bank and credit card statements they used to apply for credit cards.  

    • Citizens Medical Center unveil brand new cancer treatment technology

      Citizens Medical Center revealed their brand new state of the art cancer treatment equipment during a ribbon cutting ceremony Tuesday morning..  The Varian Edge was introduced to a crowd of supporters. The Edge, valued at $3 Million, produces precise radiation treatment, targeting only cancerous cells instead of the entire body, giving cancer patients new options for medical treatments. 

Current Conditions
/
  • Most Popular StoriesMost Popular StoriesMore>>

  • Victoria bus stop dancer finds future in figures

    Victoria bus stop dancer finds future in figures

    "I guess just going to the beat of the music I just make up my own dance," Victoria woman, Tracy Lopez said. 

    "I guess just going to the beat of the music I just make up my own dance," Victoria woman, Tracy Lopez said. 

  • Our Apologies

    The page you requested is currently unavailable. Pages on this site are constantly being revised, updated, and occasionally removed. You may have followed an outdated link or have outdated pages in your

    You have reached a page which is currently unavailable. We apologize for any inconvenience. Please use your browser's BACK button to return to the previous page

  • Cuero Senior gets surprise of a lifetime

    Cuero Senior gets surprise of a lifetime

    Its graduation time and for one Cuero highschool student, the event is made more meaningful by some surprise guests. Newscenter 25's David Gibson tells more about this touching tale. 

    Its graduation time and for one Cuero highschool student, the event is made more meaningful by some surprise guests. Newscenter 25's David Gibson tells more about this touching tale. 

  • Man arrested after pulling out silenced weapon on Main Street

    Man arrested after pulling out silenced weapon on Main Street

    A man is in custody after allegedly pulling out a silenced weapon in the middle of traffic on Main Street. According to VPD dispatch, the man pulled out the weapon after three other men attempted to confront him, around 5:30 Monday evening.  

    A man is in custody after allegedly pulling out a silenced weapon in the middle of traffic on Main Street. According to VPD dispatch, the man pulled out the weapon after three other men attempted to confront him, around 5:30 Monday evening.  

  • Birthday wishes

    Birthday wishes

    Happy Birthday to Sandra, Mandy, and Theresa.  If today is your Birthday, you share it with Drew Carey and Joan Collins. Have a good one!
    Happy Birthday to Sandra, Mandy, and Theresa.  If today is your Birthday, you share it with Drew Carey and Joan Collins. Have a good one!
  • North Carolina Highway Patrol Trooper Killed in Crash

    North Carolina Highway Patrol Trooper Killed in Crash

    A trooper was killed in an overnight crash on Interstate 77 southbound in Yadkin County, according to Chris Knox with the North Carolina State Highway Patrol.
    A trooper was killed in an overnight crash on Interstate 77 southbound in Yadkin County, according to Chris Knox with the North Carolina State Highway Patrol.
  • Primary Runoff Election Results

    Primary Runoff Election Results

    It's election night, and we have some preliminary results to tell you about. The Republican Representative for District 27 race seeming to be blow out in favor of Michael Cloud. With 35 precincts reporting, Cloud has 84 percent of the votes.  The Democratic race a little more intense. With 35 precincts reporting, Eric Holguin and Raul (Roy) Barrera are neck and neck. But Holguin appears to have pulled ahead with 53 percent. For the Democratic Gubernatorial race between ...

    It's election night, and we have some preliminary results to tell you about. The Republican Representative for District 27 race seeming to be blow out in favor of Michael Cloud. With 35 precincts reporting, Cloud has 84 percent of the votes.  The Democratic race a little more intense. With 35 precincts reporting, Eric Holguin and Raul (Roy) Barrera are neck and neck. But Holguin appears to have pulled ahead with 53 percent. For the Democratic Gubernatorial race between ...

  • Victoria County Jail Faces AC Issues

    Victoria County Jail Faces AC Issues

    Victoria County Jail has experienced issues with the AC in their facility.

    Victoria County Jail has experienced issues with the AC in their facility.